Isernia

Isernia is the second-largest city in Molise and the capital of its province. It is internationally known for the Isernia La Pineta archaeological site, uncovered in 1978 during road construction, which preserves evidence of one of the oldest known Lower Paleolithic human occupations in Europe, dated to roughly 700,000 years ago (the "Homo aeserniensis" activity there is inferred from flint and limestone tool-working and animal remains, since no human skeletal remains themselves were found). Artifacts from the site are held at the Santa Maria delle Monache Archaeological Museum, housed in a former Benedictine convent in the historic center.

• Santa Maria delle Monache Archaeological Museum (Corso Marcelli 8) — housed in a former Benedictine convent, displaying artifacts from the Isernia La Pineta Paleolithic site, one of the oldest in Europe.
• Isernia La Pineta — the Lower Paleolithic archaeological site itself, dated to roughly 700,000 years ago.

Campobasso, the regional capital, is the nearest larger city.